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These pro-inflammatory factors further damage the barriers and alter the microbiota, perpetuating the cycle of chronic inflammation ( Bacteroidetes and Firmicutes , and an upturn in Proteobacteria ( CB , FP , Clostridium lavalense , Clostridium cluster XlVa , Blautia faecis , Bacteroides uniformis , Ruminococcus torques , and Roseburia inulinivorans ( Based on existing research, intestinal Clostridium and their metabolites exert effects on IBD mainly via intestinal barrier repair, innate immunity regulation, and adaptive immunity modulation ( Clostridium -containing preparations also exhibit certain adjuvant therapeutic effects ( 3.1.1 Repair intestinal barrier and stabilize gut microbiota homeostasis Intestinal barrier dysfunction initiates IBD

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