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Kelly, T

But in high doses or in people with liver damage, this process can fail, leading to liver toxicity

Mol .Psychiatry

This is supported by compelling evidences that IGF1 replacement therapy is able to restore mitochondrial dysfunction observed in untreated cirrhotic rats and in IGF1 partial deficiency mice (Perez et al., 2008

This is very often the case for age-related hearing loss, and elderly individuals may not realize their hearing has diminished, or they may dismiss it as a normal part of aging