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While local anesthetics provide analgesia by selectively suppressing pain perception at the periphery, general anesthetics act centrally to induce loss of consciousness, amnesia, and immobility through modulation of CNS receptors such as GABA-A and NMDA [64,65,66]

Figure 3 7 Summary In recent years there has been a gradual increase in research on the glycocalyx, which is an important substance that is synthesized and secreted by vascular endothelial cells and is involved in the maintenance of endothelial structure and function

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Research has demonstrated that these age-related functional declines can be partially reversed through NAD+ restoration, with studies showing that NAD+ precursor supplementation in aged animals can restore mitochondrial function, improve cognitive performance, and extend both healthspan and lifespan

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