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2 Mechanisms of neurodegenerative diseases Neurodegenerative diseases are a group of age-related disorders characterized by highly heterogeneous pathogenesis and clinical manifestations, with progressive loss of vulnerable neurons and gradual decline in brain function ( 2.1 Genetic factors in neurodegenerative diseases Age remains a key risk factor for AD, which predominantly affects the elderly and causes significant burdens on daily living through progressive memory and learning deficits ( Furthermore, recent studies have shown that under stress from ferroptosis inducers, DJ-1 can significantly suppress ferroptosis

doi: 10.1073/pnas.92.12.5510 296 WangX.SchwartzJ

Studies have demonstrated measurable lipolytic activity in adipose tissue while confirming the absence of significant changes in blood glucose, insulin sensitivity, or IGF-1 levels, validating its utility as a targeted research tool for studying fat metabolism pathways independently of growth axis effects

Inhibition of lipid oxidation increases glucose metabolism and enhances 2-deoxy-2-[18F]fluoro-d-glucose uptake in prostate cancer mouse xenografts