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Hentze, M.W., Muckenthaler, M.U., Galy, B

Disclosures: Qing-Lei Zeng: Nothing to Disclose, Ru-Yue Chen: Nothing to Disclose, Xue-Yan Lv: Nothing to Disclose 431 INNATE IMMUNITY PLAYS AN IMPORTANT ROLE IN THE INACTIVE CHRONIC HBV CARRIERS WITH POSITIVE HBEAG AND HIGH HBV DNA DURING TAF TREATMENT Qiumin Luo 1 Wenxiong Xu 1 Yeqiong Zhang 1 Chan Xie 1 Liang Peng 1 , 1 Sun Yat-sen University Background: The innate immune mechanisms that affect the efficacy of TAF treatment in chronic HBV carriers with normal ALT and high HBV DNA load deserve more exploration

Es gestaltet sich als herausfordernd und kostenintensiv, die Konzentration von Glutathion im Blut mittels oral verabreichter Prparate zu erhhen, da das Enzym Gamma-Glutamyltranspeptidase im Darm vorhanden ist und Glutathion dort abbaut

An increase in red blood cell GSH (to 2.20 1.10 mM/L from a baseline of 1.60 0.97 mM/L) and a decrease in cysteine content (to 65 14 M/L from 122 42 M/L) was demonstrated