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Design, synthesis of novel azolyl flavonoids and their protein tyrosine Phosphatase-1B inhibitory activities Bioorg

In hepatocellular carcinoma (HCC) cells, ketoconazole downregulates the expression of COX2, thereby triggering PINK1-Parkin-mediated mitophagy to enhance apoptosis, downregulate BCL2, BCL-XL and MCL1 and upregulate BAX and BAK [25] (Fig