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Curcumin can reduce LPS-induced inflammation in vascular smooth muscle cells via TLR4-MAPK/NF-B pathways by inhibiting ROS generation ( Oral supplementation with curcumin reduces OS generated by hyperthyroidism in rats, as shown by decreased LPx and protein carbonyl (PC) levels and increased SOD and CAT activities in tissues ( In vitro studies show that curcumin can boost cellular glutathione levels by stimulating the transcription of two Gcl genes ( Gclc and Gclm ) encoding glutamate cysteine ligase, which is the rate-limiting enzyme in glutathione synthesis (152)

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Our study suggests cross talk between stromal regulation of glycolysis and TGF- signaling