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Schwann cells, the support cells that form myelin sheaths around nerve fibers, shift from their normal myelinating role to a repair phenotype

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The growth inhibitory effect of ACA could be rescued by inhibitors of autophagy (bafilomycin A1 and chloroquine) and ferroptosis (liproxstatin-1 and ferrostatin-1), but not by inhibitors of necrosis (NSA) or apoptosis (Z-VAD-FMK) (Supplementary Fig