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The major phase of enzymatic detoxification in many species is the conjugation of activated xenobiotics to reduced glutathione (GSH) catalyzed by the glutathione- S -transferase (GST)

They found overall low levels of risk, consistent with the findings of other investigators who performed risk assessments following oil spills

549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

Furthermore, in liver cancer and metastatic melanoma cells, GSH status is correlated with growth [3335] and it has also been demonstrated that a direct correlation between GSH levels associated with cellular proliferation and metastatic activity exists [33]

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