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For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)

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Moreover, PGE2 released by tumors upregulates CD73 expression in monocytic MDSCs, leading to increased suppression of T cell activity through elevated adenosine levels