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In this study, we describe metabolic rewiring in MYCN -amplified adrenergic neuroblastoma cells, where high consumption of cysteine used for the synthesis of cellular building blocks at the expense of GSH synthesis and ROS clearance creates a new MYCN -dependent liability

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10.1038/nn.3960 113 XuC.HouP.LiX.XiaoM.ZhangZ.LiZ.et al (2024)

Reconstitution math, syringe volumes, and injection technique are not academic details: get any of them wrong and the result ranges from an ineffective product to a genuine safety risk