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Too much uric acid in the blood, however, can end up causing pain, swelling, or inflammation

10.1586/14737175.6.2.247 35 Enriquez-GeppertS.HusterR

However, despite this unique metabolic specificity, the implementation of 13 C-MRS in human studies has been limited by three major technical challenges 812 : its inherently low sensitivity (due to the lower gyromagnetic ratio of 13 C compared to 1 H), the requirement for high-power broadband radiofrequency (RF) excitation, and the need for specialised and costly RF hardware 13

Our twoperiod, doubleblind crossover design permitted a longitudinal profiling of cytokine trajectories across four visits, in marked contrast to crosssectional investigations that provide only a single snapshot of ocular inflammation

Springer, Heidelberg, pp 4572 Lange SC, Bak LK, Waagepetersen HS, Schousboe A, Norenberg MD (2012) Primary cultures of astrocytes: their value in understanding astrocytes in health and disease