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It downregulated the expression of the lipogenic enzyme monounsaturated fatty acid synthase (SCD-1) and upregulated the expressions of key genes for triglyceride synthesis, such as sterol regulatory element-binding protein 2 (SREBP-2) and the cholesterol synthesis gene -hydroxy--methylglutaryl-CoA synthase (HMGCS), which led to the inhibition of cholesterol synthesis and the reduction of lipid accumulation (Chao et al., 2020

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Owing to their small size (1-100 nm) and high surface-to-volume ratio, nanomaterials possess specific properties determining unique nano-bio interactions

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Ann Thorac Surg 109: 1628, 2020

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