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SP-A and SP-D bind to toll-like receptors that recognize pattern-associated molecular patterns bound to RNA from viruses, and lung collectins and MBL cause (a) virion agglutination, inhibition of infectivity and dissemination, and (b) subsequent alveolar macrophage and neutrophil-mediated removal (5658)

However, they work best as part of a broader approach that includes regular exercise, balanced nutrition, quality sleep, and stress management.

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As the experimental findings that have not been obtained by studying systems have been confirmed by in vivo investigations, further work is strongly needed