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Nevertheless, the alymphoplasia mice, harboring loss-of-function mutation of NIK, display severe defects in the immune system, including impaired lymphoid organ development, B cell survival, and antibody production, associated with deficiencies in both the humoral and cellular immune responses against infections [3, 4]

Another rehabilitation study incorporating complex decongestive therapy (CDT) alongside home-based exercise showed positive results in improving fatigue, leg strength, and mobility, particularly among patients with secondary lymphedema, without exacerbating edema [211]