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Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

Activation of these receptors enhances burst firing in dopaminergic neurons, increases dopamine release in the nucleus accumbens, thereby forming rewarding signals for external stimuli such as nicotine ( 5 , 3 , and 4 subtypes similarly play negative regulatory roles in nicotine uptake and aversive effects (Sheffield et al., 2000)

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