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The latter transcriptionally regulates genes related to inflammation and oxidative stress (e.g., GPx and GST, among others) (69)

Activated microglia will in turn release pro-inflammatory cytokines (TNF-, IL-1 and IL-6), colony-stimulating factor 1 (CSF1), brain-derived neurotropic factor (BDNF), reactive oxygen species (ROS) among others into the spinal cord micro-environments, to direct multidirectional crosstalk between primary afferent, interneurons, secondary neurones, astrocytes and microglia