glutathione and mitochondrial function (GSH), a powerful intracellular antioxidant, plays a Mitochondrial Glutathione in Cellular Redox

However, it remained possible that normal levels of TrxR2 protein, though perhaps lower than normal levels of TrxR1 protein (see above), might be sufficient to compensate for loss of TrxR1 without an associated increase in mRNA levels

Regular use may help improve the appearance of dark spots and uneven skin tone by supporting antioxidant balance and skin health

5.2.4 Ferroptosis suppressor protein 1 and coenzyme Q10 pathway FSP1 possesses NAD(P)H oxidoreductase activity and reduces CoQ to ubiquinol (CoQH2), which inhibits lipid peroxidation and ferroptosis by trapping lipid peroxidation free radicals (77, 78)

I think first you need to know your skintype, concern and skintest them

A growing list of molecular targets, including PKD [118], PARP1 [25], Padi4 [46], HMGB2 [44], WTAP [42], METTL3 [66], SP2509 [80], BRD4770 [72], LDHA [71], KLF15 [89] and others, further expands the therapeutic landscape of ferroptosis regulation and intervention