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Step 3: Establish a consistent window

30 Initially, HIF-1 activates lactate dehydrogenase A (LDHA) and glucose transporters to facilitate the transformation of the metabolic pathway from oxidative to non-oxidative carbon metabolism as well as ATP-producing pathways (glycolysis)

doi: 10.3389/fphys.2021.637480 77

All mice were bred and housed in a specific pathogen-free barrier facility at the University of Washington, Seattle

Some changes in the original diet have occurred over time, but the initiation phase of the diet has always been a vegetarian diet.[2] Taking specific vitamin and mineral supplements plus pancreatic enzymes is the second component of the regimen