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A proposal of integration of biomarkers into MASLD staging and treatment monitoring is presented in Figure 3

and B.J

Lalo et al., 2006

Lyophilised compound preparation

68 Conversely, the estrogen metabolite 16-hydroxyestrone exacerbates the effects of the Bmpr2 R899X mutation, leading to increased miR-29 levels in mouse lungs, decreased expression of CD36 and PPAR in PMVECs, and heightened ceramide deposition in lung tissues, contributing to aberrant cellular metabolism and promoting PAH in Bmpr2 mutant mice