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Moreover, the myokine-mediated pathway from skeletal muscle to the brain facilitates cognitive enhancement through the regulation of adult hippocampal neurogenesis and synaptic plasticity, with older adults demonstrating the most significant therapeutic gains [32, 185]

A prior in vivo investigation revealed that when the olfactory bulbs were removed, COVID-19s entry into the CNS was reduced, which demonstrates that the virus invades the CNS through this pathway [12]