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Interestingly, to counteract the excitotoxic insult various studies demonstrate that an enhanced GABAergic tonus i.e., by administration of GABAergic agents prior to ischemia or shortly after the ischemic episode provides neuro protection in preclinical stroke models (Corbett et al., in vitro neuroprotective role through mechanisms of GABA A receptor subunit upregulation and increased post-ischemic cell-surface receptor stability, respectively (Mielke and Wang, 2005

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