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Pyrroloquinoline quinone attenuates fat accumulation in obese mice fed with a high-fat diet, daphnia magna supplied with a high amount of food, and 3T3-L1 adipocytes

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Aptamers are thermostable and chemically stable, and chemical modification can enable their conjugation to nanoparticles, drugs, or other nucleic acid drugs to improve cellular uptake

In 3T3-L1 adipocyte cell models, 5-Amino-1MQ at 30 M concentration produced significant reductions in intracellular 1-MNA levels, confirming target engagement