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A study by Creager et al

457 The production of iron-dependent hydroxyl radicals has been associated with muscle necrosis in a mouse model of DMD, and iron deprivation can decrease muscle necrosis and has potential therapeutic benefits

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doi: 10.1186/s12883-019-1276-8

In this environment, NLRP3 inflammatory vesicles are activated and release pro-inflammatory mediators, which trigger a neuroinflammatory response (167)