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In addition, reproductive dysfunction caused by WD is primarily characterized by hypogonadism and teratozoospermia, which are linked to mechanisms such as inflammation, pyroptosis and apoptosis triggered by copper deposition (86-88)

161 A small molecule called divertin, which can bind specifically to the immunoglobulin-like occludin cell adhesion molecule (IgCAM) of epithelial long MLCK1, was shown to prevent cytokine-mediated MLCK1 recruitment to PAMR without interfering with other facilitative mechanisms (e.g., epithelial migration and wound repair)