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Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis

Cell Death Differ 17:13731380

The Journal of the American Medical Association, 294 , 5665

Research has shown that following bone injury, there is a marked increase in ROS levels, which peak during the healing phase and then progressively return to baseline values ( in vitro expansion or in vivo transplantation, cells confront excessive ROS levels