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Isoform-selective NOX inhibitors: advances and future perspectives, in NADPH oxidases revisited: from function to structure

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13.3 Immunomodulatory mechanisms and novel applications Curcumin shifts macrophages from pro-inflammatory (M1) to anti-inflammatory (M2) phenotypes by suppressing TLR4/NF-B and JAK-STAT pathways, reducing IL-6, TNF-, and nitric oxide production