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Elevated polyamine levels, particularly SPD, correlate with extended lifespan and improved physiological resilience across model organisms, and altered polyamine metabolism is consistently linked to neurodegenerative and cardiovascular ageing [219,220]

10.1371/journal.pone.0053165 204 WangJ.UddK

Additionally, TKP reduced the level of MDA, and enhanced the activities of SOD and GSH-Px, effectively attenuating oxidative stress

This could explain the plasma membrane translocation of arrestin 3-GFP observed in the study of Navratilova and colleagues with the S363A DOR mutant (Navratilova et al., 2007)