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Even though lesions persisted relatively unchanged in 16% of the patients, they still reported some alleviation in symptoms, suggesting that ozone therapy might be an effective alternative to more invasive interventions, such as bone ablation surgery, particularly for bisphosphonate-induced related jaw osteonecrosis cases [51]

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Local treatment with Botulinum toxin-A has been reported to block the union of presynaptic membrane and vesicles, leading to increased tumor perfusion and oxygenation by inhibiting norepinephrine production at the neuromuscular junction

Zavodnik, I.B., Dremza, I.K., Lapshina, E.A., and Cheshchevik, V.T., Zh

Furthermore, another review highlighted the involvement of EVs in COPD pathogenesis, particularly their influence on inflammation, immune responses and airway remodeling (109)