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Aggregated panel responses formed the basis of the final recommendations, which are intended to provide clinicians an experience-driven guidance for practical application

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Both in vitro and in vivo assay demonstrated that METTL14 induced N6 -methyladenosine (m 6 A) modification at 5UTR of SLC7A11 mRNA, which promotes SLC7A11 mRNA stability and upregulates its expression by inhibiting the deadenylation process, enhancing ferroptosis resistance (Fan et al., 2021

Gut dysbiosis has emerged as a particularly compelling area, with Mendelian randomization studies now confirming causal links between specific gut microbiome compositions and tinnitus risk [2]