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In recent years, the scientific community has focused on two key endogenous molecules NAD (Nicotinamide Adenine Dinucleotide) and reduced glutathione (GSH) whose progressive depletion with age is now correlated with the main signs of cutaneous and systemic ageing. NAD: the anti-ageing metabolic powerhouse NAD is an essential coenzyme involved in hundreds of redox reactions and a fundamental substrate for sirtuins and PARPs, pro-longevity enzymes that regulate DNA repair and mitochondrial function

While CITF1 transcript levels increase under Cu deficiency and decrease under sufficiency, partially in an SPL7-dependent manner, AtSPL7 itself is expressed constitutively, suggesting its posttranscriptional regulation under Cu deficiency (Shikanai et al., Reference Shikanai, Mller-Moul, Munekage, Niyogi and Pilon2003

Arkbage, et al

Gastric, BCI vs