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Since oxidation and inflammation are interconnected processes with many feedback loops 50 , excessive production of ROS and RNS by leukocytes can also trigger inflammatory responses in these immune cells

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130 Comparatively, the deficiency of ZIP8 has a substantial impact on zinc influx in effector T cells and results in reduced TCR-mediated signaling, including NF-B and MAPK signaling, which are involved in the differentiation of T helper (Th)17 cells