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Laboratory studies suggest that these interactions may influence phosphorylation events and signal transduction processes that regulate endothelial behavior, vascular tone signaling, and angiogenic pathway activity

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For example, DTPs surviving therapy in residual disease (RD) express the alveolar-regenerative gene signatures, including HOP homeobox and insulin-like growth factor binding protein 2 (IGFBP2) for alveolar type 1 cell features, as well as aquaporin 4 (AQP4), surfactant protein B/C/D (SFTPB/C/D), Claudin 18 and forkhead box A2, NK2 homeobox 1 for alveolar type 2 cell features, indicating a therapy-induced primitive cell-state transition [57]

162 (3) is an indirect route connected to the systemic circulation involving the gastrointestinal and respiratory systems

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