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A significant expansion of M1 inflammatory macrophages and depletion of plasmacytoid dendritic cells (DCs) were reported in patients sensitive to treatment with daratumumab-Pd, using a single-cell sequencing approach [37]

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Superoxide is subsequently converted to hydrogen peroxide (H 2 O 2 ), a more stable and stronger oxidizing molecule, through the action of superoxide dismutase enzymes (SOD)

Because of the defect in expression of activation markers including CD38, NKp46 and NKp30, g-NK cells act as memory-like cells, with less IFN- secretion than activated cNK cells, but have stronger antitumor potential than cNK cells after CD16 crosslinking [53]