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This deficiency triggers the excessive release of cyclophilin A (CypA), which perturbs TJ protein localization and activates MMPs to degrade the basement membrane (90)

found that arecoline, as the pathogenic component of OSF, can upregulate the levels of PA28, BRAF, and phosphorylated MEK1 protein, which interact with each other to form a protein complex, thus activating MEK1/ERK signaling pathway and promoting EMT in oral epithelial cells