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Topically applied hydroquinone-containing creams may give rise to accumulation of these compounds, which can cause DNA damage and mutations

[8] Estimates of transformation into melanoma vary from 2-42% in the literature, but are most commonly considered to be at the low end of that spectrum due to early observer bias

Pestel, S., Schlaf, G., Gtze, O., Jungermann, K

Abbreviations OM: Oral mucositis EDO: Edaravone DOX: Doxorubicin ROS: Reactive oxygen species Ang II: Angiotensin II OD: Optical density SD: Standard deviation SOD: Superoxide Dismutase MDA: Malondialdehyde TAS: Total Antioxidant Status TOS: Total Oxidant Status IL-6: Interleukin-6 IL-1: Interleukin-1 IL-10: Interleukin-10 NF-b: Nuclear Factor kappa B SIRT1: Sirtuin-1 TLR4: Toll-like Receptor 4 TNF-: Tumor Necrosis Factor- References -Berger AM, Kilroy TJ

Using laxatives can be helpful in the short term but it is far more beneficial to address the underlying issues of constipation and correct fluid and fibre intake or address food intolerances, particularly dairy containing foods which can often be the culprit