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In its Complete Response Letter, the regulator said the data was insufficient because a third-party clinical site operator destroyed data source documents for about half of the subjects enrolled in the vaccines trial, according to Reuters

[1] [22] [23] This high rate of spine turnover may characterize critical periods of development and reflect learning capacity in adolescencedifferent cortical areas exhibit differing levels of synaptic turnover during development, possibly reflecting varying critical periods for specific brain regions

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