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For decades, methotrexate has been used as a standard of care treatment for cancer patients (Newman and Maddocks, More recently, it has been established that the repression of tumor suppressor genes by methylation, which is dependent on SAM levels, is a key-initiating event for many cancers (Kulis and Esteller, De novo serine synthesis has also been identified as a metabolic vulnerability of many cancers, including non-small cell lung cancer (NSCLC), breast cancer, and melanoma (Locasale et al., Glycine metabolism has also been shown to be important in cancer development and growth

J Nutr 134:489492 Yamaoka Y, Takimura O (1990) Manufacture of glutathione with green algae Dunaliella

Glutathione helps maintain cellular health, controls inflammation, and keeps the immune system functioning optimally, preventing illness

(2012) The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state, Blood , 120 , 2631-2638, doi: Wang, F., Li, L., Chen, Z., Zhu, M., and Gu, Y

Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells