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Furthermore, MIP-3 expression is mainly distributed in the renal tubules and is responsible for activated macrophage infiltration (50)

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doi:10.1097/01.Jaa.0000511800.91372.34

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Using ex vivo models, metformin treatment significantly inhibited oxidative phosphorylation and glycolysis in treatment nave rectal cancer biopsies, without affecting the real-time metabolic profile of non-cancer rectal tissue