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Despite promising regenerative outcomes in animal modelssuch as achieving NP cell survival rates reaching 85%, a 3.3-fold increase in COL2 synthesis, and 87% recovery of disc height through spatiotemporally controlled release, ROS scavenging, and immune modulationsignificant challenges remain for clinical translation

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Neuroprotection of developing brain There is an urgent need for therapies that can improve outcome after neonatal and pediatric brain injury as current therapies are only partially effective [134, 135, 169172]