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This model presents a DMD skeletal muscle phenotype with age-related decline in strength/power, elevated creatine kinase levels, muscle necrosis, and respiratory issues caused by diaphragm degeneration 6

Chung 1 , Volney Spalding 2 , Brian A Fellenstein 2 , Andre Jeyarajan 2 , Lishan Su 3 , Nadia Alatrakchi 1 , Wenyu Lin 1 and Guangming Li 3 , (1)Massachusetts General Hospital and Harvard Medical School, (2)Massachusetts General Hospital, (3)University of North Carolina at Chapel Hill Background: The successful implementation of antiretroviral therapy has shifted the focus of human immunodeficiency virus-1 (HIV-1) research towards the long-term effects of persistent, controlled infection