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Endotoxin safety screening Gel-clot Limulus Amebocyte Lysate (LAL) test to detect bacterial endotoxins or lipopolysaccharides (LPS)

Notably, this study identified coordinated upregulation of TGR5 in subcutaneous adipose and jejunal tissues with core lipogenic genes ( PPAR , SREBP-1c ) in the RPG group, suggesting a novel signaling cascade: RPG activates jejunal TGR5 signaling, inducing secretion of INS, GLP-1, and 5-HT, which amplify the activation of master regulators ( PPAR , SREBP-1c ), ultimately driving systemic lipogenic gene networks [66, 67]