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8,20 Ferroptosis is triggered by inhibiting cell membrane translocators such as cystine/glutamate translocators (also known as system Xc-) or by activating transferrin, as well as by blocking intracellular antioxidant enzymes such as glutathione peroxidase 4 (GPX4)

In fact, even a single point mutation of the conserved Cys residues is sufficient to reduce the activities of DNA primase and DNA polymerase

Interestingly, ASD children with the blocking FRAA appear to have a more favorable redox and inflammation profile with relatively better glutathione and CT indices than FRAA blocking negative children

Lopez-Otin, C., Blasco, M

Pak J Nutr 18:247253 Ross IA (2023)The Bioactive components of plants, plant-based therapeutics, Volume 1: Cannabis sativa