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10.1016/j.ejphar.2023.176264 86 PengC.FuX.WangK.ChenL.LuoB.HuangN.et al (2022)

Difficult-to-treat AIH (DTT-AIH) refers to cases where the standard first-line treatment is ineffective, poorly tolerated, or leads to frequent relapses

TLK is a key regulator of calcium overload in Drosophila To screen for genetic modifiers against the calcium-overload-mediated cell damage, the wing posture defects were quantified

However, it should not be ruled out that SARS-CoV-2 mRNA vaccines could also generate autoimmune responses in genetically susceptible individuals upon exposure to viral antigens, as observed in some cases (7681), but as the mRNA degrades and does not persist in the organism (88), the long-term autoimmune sequelae could be limited and disappear once the triggering antigen is removed, as occurs in many cases of ASIA syndrome (64, 74) 5 Similarity in genetic predisposition Single nucleotide polymorphisms (SNPs) in several genes associated with autoimmune diseases have been observed in patients with ME/CFS (54)

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