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Oral semaglutide barely crosses the blood-brain barrier and the trials enrolled people relatively late in the disease, so a negative treatment result does not settle the prevention question

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Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial

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Specifically, several factors which can cause aggregation include but are not limited to shaking, shearing, temperature, pH level, and protein concentration 23, 24