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Key transcription factors regulating the expression and induction of GCLC by pro- and anti-oxidants include nuclear respiratory factor NRF2/NRF1, activator protein-1 (AP-1), and nuclear factor kappa B (NFB)

To exclude the loss of components during the fractionation procedure, the solute and eluate of CAF-CM were re-pooled together and tested

Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology

Variants in GSS cause GSS protein deficiency or reduced GSS activity, resulting in lower GSH levels

Interestingly, these changes were accompanied by marginal increases in 15LO1 ( P = 0.082), potentially further contributing to GSH oxidation (Figure 4B)