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It is important for growth and muscle endurance (biosynthesizes proteins useful for physiological muscle well-being), stimulates protein synthesis, supports the metabolism and is a primary energy source in stress due to both efforts (work and sport) and consequent to pathologies

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55,57 These injured or profibrotic tubular cells recruit macrophages, lymphocytes, and fibroblasts, promoting tissue fibrosis and leading to irreversible kidney damage