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Administration of Sativex an approved oromucosal spray (Health Canada and various European health agencies) containing THC (5 mg/kg) and CBD (5 mg/kg) for the treatment of symptoms associated with MSreduced astrocyte reactivity and decreased the expression of pro-inflammatory cytokines released by microglia in a mouse model of MS (Feli et al., 2015)

This comparable activity may be attributed to the similar total phenolic content present in both extracts

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Another study also demonstrated that anxiety, depression and cognitive impairments induced by psychosocial stress are ameliorated by quercetin and also by modulating plasma corticosterone and adrenocorticotropic hormone levels, as well as corticotropin-releasing factor (CRF) mRNA expression in the hypothalamic region [183]

1) were assessed by pathway enrichment in MetaboAnalyst 6.0 using the Small Molecule Pathway Database (SMPDB) with 99 metabolite sets from normal human metabolic pathways and was enriched for Methionine Metabolism, Phenylacetate Metabolism, Pantothenate and CoA Biosynthesis, Pyrimidine Metabolism, Glycine and Serine Metabolism, Arginine and Proline Metabolism, Riboflavin Metabolism and Betaine Metabolism (Fig