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CO is able to reduce pro-inflammatory cytokines attributing to the toxicity of free heme including TNF-, IL-1 and IL-2 through its actions on MAPK and NF-k pathways (Kruger et al., 2006

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All products are supplied exclusively under the RUO exemption in FDA Guidance "Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only" (2013) and 21 C.F.R