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Although the pentose phosphate pathway and glycolysis are well recognized as the primary sources of NADPH that contribute to redox balance, the folate cycle ( Figure 3 )which is mostly sustained by serine-derived one-carbon unitsalso generates a significant amount of NADPH (238)

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This interference effectively blocks androgen-dependent gene expression essential for normal male reproductive development ( 3.1.1.2 Estrogen receptor modulation Polychlorinated biphenyls exhibit differential binding affinities for estrogen receptor subtypes, with ER demonstrating an EC50 of 0.8 M and ER showing an EC50 of 1.2 M